The 10/10 Piccolo / Price Rhymes With Orange cartoon is delightful, but incomprehensible if you don’t know the proverb whose standard form is now Curiosity killed the cat:
(#1) If you see that the proverb is the key to understanding the cartoon, you’ll be able to appreciate the pun on curiosity — with one sense given explicitly in the cartoon (in curiosity shop), the other available only implicitly, through the proverb and the reference to killing in the cartoon
The two senses, from NOAD:
noun curiosity: 1 a strong desire to know or learn something: filled with curiosity, she peered through the window | curiosity got the better of me, so I called him. 2 a strange or unusual object or fact: he showed them some of the curiosities of the house.
Sense 2 gives us curiosity shop, a store (like the one in the cartoon) that offers curiosities for sale; and cabinet of curiosities, a collection of curiosities for display. And from sense 2 we get the noun curio for the sorts of thing (visible in the cartoon) on sale at a curiosity shop:
noun curio: a rare, unusual, or intriguing object: they had such fun over the wonderful box of curios that Jack had sent from India. ORIGIN mid 19th century: abbreviation of curiosity. (NOAD)