To fully appreciate this cartoon (passed on to me on Facebook), you need to have two pieces of pop-cultural knowledge, one originally American, one originally British (though it is the way of such things to cross the Atlantic culturally):
You need, of course, to recognize — American cultural knowledge — that this is a baseball diamond, with a game in progress, and that there’s an object on first base. Then — further American cultural knowledge — you need to recognize the (note: declarative, not interrogative) sentence Who’s on first as the first move in one of the greatest America comedy routines ever. Then — British cultural knowledge — you need to recognize the thing on first base and connect it to the fact that Who’s on first, both of them elements from one of the most popular British tv shows ever.






